Serum adenosine deaminase and arylsulfatase A as an index of early infiltration of central nervous system in acute lymphoblastic leukemia

The level of adenosine deaminase [ADA] and arylsulphatase A [ASA] in the sera of 22 patients with acute lymphoblastic leukemia [ALL] were significantly increased when compared with the control healthy group. Also, there is a significant increase in the activity of these enzymes in patients with ALL with central nervous system [CNS] infiltration when compared with patients of ALL without CNS infiltration. We conclude that the estimation of ADA and ASA in the serum may be useful for detection of the early infiltration of the central nervous system by leukemic cells in acute lymphoblastic leukemia

effect of dimethylnitrosamine on the activities of renal puenolsulfotransferase and arylsulfatases A and B in schistosoma mansoni infected mice

The activities of renal phenolsulfotransferase and arylsulfatases A and B were estimated in 400 male Swiss albino mice classified into four groups: Normal controls, Schistosoma mansoni infected group, Dimethylnitrosamine [DMN] treated group and infected treated group. The activity levels of the studied enzymes were significantly increased in all groups when compared with the control group, also the statistical analyses showed a high significant increase of the three enzymes levels in the infected treated group; when compared separately with treated or infected groups. It was concluded, therefore, that schistosomal infection is implicated in the development of kidney cancer which may arise from the pattern of hepatic mixed-function oxidase induction characterized for schiatosomiasis and its temporal relationship with the procarcinogenic initiating events. Furthermore, the striking significant increase in the enzymatic activity levels of the acid hydrolases arylsulfatases due to the lesion of both cytotoxic effects of dimethylnitrosamine as well as pathological change of schistosomiasis which may play an active role in the initiation of the malignant process by detoxifying endogenous sulfated aromatic metabolites

Biochemical and histopathological studies on the effect of some pesticides on pancreas of male rats

The effects of two classes of insecticides were studied on the pancreas of male rats through an evaluation of blood Sugar level and serum amylase activity. Carbamate thiodicarb, represented by larvin in a single or repeated doses produced hyperglycemia, and showed a significant increase in the amylase activity. The synthetic pyrethroid cypermethrin produce hyperglycemia after single dose, while repeated dose produce hypoglycemia. The amylase activity is significantly increased by single dose only, while repeated dose had no effect. This biochemical data was confirmed by histopathological changes in the pancreatic tissue, suggesting that these insecticides have a diabetogenic effect

The lipid profile of the sera of patients with Buerger's disease and atherosclerosis

Thirty patients with Buerger's disease aged between 27- 45 years, and 30 other patients with atherosclerosis aged between 49-70 years were studied for their lipid profile compared to two corresponding control groups of similar age and sex. Total lipids and triglycerides concentrations were significantly increased in the sera of all atherosclerosis patients and exhibited normal levels in the sera of Buerger's disease, while total phospholipids, phosphatidyl ethanolamine and lipid peroxides were increased in both Buerger's and atherosclerotic patients. Sphingomyelin increased in Buerger's disease and decreased in atherosclerosis, Lysolecithin did not change in Buerger's disease but decreased in atherosclerosis. On the contrary, phosphatidyl choline decreased in Buerger's disease and did not change in atherosclerosis. However total cholesterol did not change significantly in both diseased groups. The aforementioned findings could be used as diagnostic parameters for Buerger's disease and as a discrimination tool to differentiate between Buerger's disease and atherosclerosis